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后基因组时代药理学研究趋向 被引量:2

Trends in the Post-genomic Pharmacological Research
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摘要 药理基因组学 (药物基因组学 ,pharmacogenomics)将成为后基因组时代药理学研究的新领域。与此相应 ,高通量筛选 (high throughputscreening ,HTS)、insilico研究以及多种功能可视化技术已开始成为药理学研究的新方法。本文同时介绍上述新思路与新方法应用于药效学。 With the advent of post genome era, pharmacogenomics will be a new field in pharmacological sciences. In parallel, high throughput screening, in silico research, as well as lots of visualization techniques are emerging as novel approaches in pharmacological researches. Some progress in the implementation of aforementioned new idea and methods in pharmacodynamics and pharmacokinetics research are also introduced in this review.
出处 《生理科学进展》 CAS CSCD 北大核心 2002年第1期7-11,共5页 Progress in Physiological Sciences
基金 国家重点基础研究发展规划 (973)项目G19990 5 40 0 3子课题资助
关键词 药理基因组学 高通量筛选 药效学 后基因组时代 药动学 研究方向 Pharmacogenomics High throughput screening Pharmacodynamics Pharmacokinetics
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参考文献20

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同被引文献26

  • 1陈蓁,王锐平,贺浪冲,徐迪琴.细胞膜色谱法筛选红花中的有效成分[J].陕西中医,2004,25(7):643-644. 被引量:17
  • 2贺浪冲 耿信笃.细胞膜受体色谱法—研究药物与受体作用的新方法[J].生物医药色谱新进展,1996,3:8-9.
  • 3Pickar D, Rubinow K. Pharmacogenomics of psychiatric disorders[J]. Trends Pharmacol Sci,2001,22(1):75-83.
  • 4Taylor D L, Woo E S, Giuliano K A. Real-time mole-cular and cellular analysis: the new frontier of drug discovery[J]. Curr Opin Biotechnol,2001,12(1):75-81.
  • 5YU Yue-ping,XU Qiu-qin,ZHENG Ming-zhi,et al(俞月萍,徐秋琴,郑鸣之,等). Light transmission measurement of focal ischemic cerebral infarction in mice[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002,31(2):91-93.(in Chinese)
  • 6YAN Le-qin,WEI Er-qing,HU Hai-tao,et al(严乐勤,魏尔清,胡海涛,等). Novel quantitative method for evaluating oxygen/glucose deprivation-induced injury of hippocampal slices[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002, 31(2):81-85.(in Chinese)
  • 7YU Guo-liang,WEI Er-qing,HE Wei(余国良,魏尔清,何巍). A quantitative method for evaluating brain injury and neuroprotective drugs in brain slices of mice[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002, 31(2):86-90.(in Chinese)
  • 8WANG Meng-ling,WEI Er-qing,YANG Xiao-hong,et al(王梦令,魏尔清,杨晓红,等). Optical recording method for evaluation of neuronal damage in rat hippocampal slices during ischemia and reperfusion[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002, 31(2):94-97.(in Chinese)
  • 9XU A-jing,CHEN Zhong,LI Ren,et al(徐阿晶,陈忠,李韧,等). Effects of TAK-147, a novel acetylcholinesterase inhibitor, on spatial memory deficits as evaluated by Morris water maze of rats[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002, 31(2):98-102.(in Chinese)
  • 10ZHANG Li-hui,WEI Er-qing(张丽慧,魏尔清). Time course of brain damage and expression of related molecules in the rats with transient global cerebral ischemia[J]. Journal of Zhejiang University (Medical Sciences) [浙江大学学报(医学版)],2002, 31(2):77-80.(in Chinese)

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