风湿仙丹治疗类风湿性关节炎53例临床观察

Clinical observation on 53 cases of rheumatoid arthritis treated with Feng Shi Xian Dan

根据温补与清补相结合、阴阳双补,佐以活血化痰解毒的原则配伍成风湿仙丹,治疗类风湿性关节炎(RA)53例,并与用消炎痛治疗的53例作对比观察。结果治疗组治愈显效率54.7％,总有效率92.4％,对照组分别为26.4％和66.0％,两组疗效差异有显著性(P<0.01);临床主要症状体征改善程度除关节疼痛个数外均优于对照组(P<0.05或P<0.01);血沉(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)、免疫球蛋白、T淋巴细胞亚群、甲襞微循环和出现贫血患者的红细胞(RBC)、血红蛋白(Hb)改善的幅度均明显优于对照组(P<0.05或P<0.01);两组治疗前红细胞超氧化物歧化酶(SOD)和血浆脂质过氧化物(LPO)均较正常组有明显差异(P<0.05或P<0.01),治疗后治疗组SOD、LPO水平较治疗前明显趋于正常(P<0.05或P<0.01),且治疗组LPO下降幅度显著优于对照组(P<0.01);治疗组除极少数有轻微的消化道症状外,无其它不良反应,而对照组有较多的不良反应。说明风湿仙丹对RA有显著疗效,不仅能控制RA的症状,而且能改善其病理损害并阻止其发展,且副作用少,值得推广应用。

Feng Shi Xian Dan was used for treatment of 53 cases of rheumatoid arthritis (RA), and indomethacin was used for treatment of 53 cases as control. Results showed that the markedly effective rate and the total effective rate were 54. 7 % and 92. 4% in the treatment group, and 26. 4% and 66. 0% in the control group, respectively, with a significant difference between the two groups in the therapeutic effect (P<0. 01). The improvement extent of the clinical main symptoms and signs, except joint numbers of pain, in the treatment group was superior to that in the control group (P<0. 05 or P<0. 01) : blood sedimentation rate, rheumatoid factor (RF), C response protein ( CRP ), immunoglobins (Ig ), T- lymphocyte subpopulations, microcirculation of nail fold, and red blood cell (RBC) and hemoglobin in the patient of anemia were significantly superior to that in the control group (P<0. 05 or F<0. 01) ; there were significant differences in the two group in superoxide dismutase (SOD) activity and lipid hyperoxide (LPO) level before treatment as compared with the normal group OP<0. 05 or P<0. 01), and after treatment SOD activity and LPO level tended significantly to normal (P<0. 05 or P< 0. 01) in the treatment group, and the lowering amplitude of LPO in the treatment group was significantly superior to that in the control group (P<0. 01) ; the treatment group had no adverse reaction except less cases had symptom in digestive tract. It is indicated that Feng Shi Xian Dan has an obvious therapeutic effect on RA.