剂量率对全身照射效果影响的探讨

The Influence of Dose Rate for Total Body Irradiation Effect

[目的]探讨不同剂量率射线对全身照射 (TBI)效应的影响。[方法]回顾分析67例恶性淋巴瘤、白血病患者的临床资料 ,其中自1995年7月～1999年2月采用剂量率3.8cGy/min～6.0cGy/min(低剂量率组 )进行TBI37例。自1999年3月～2001年6月采用剂量率10cGy/min～11.32cGy/min29例 ,22.6cGy/min1例共30例 (高剂量率组 )进行TBI。TBI总量7Gy～8Gy。[结果]骨髓移植均一次性植活。骨髓移植并发症的发生率 ,两组比较其差异无统计学意义。高剂量率组的复发率低于低剂量率组 (P<0.05)。[结论]采用10cGy/min剂量率 ,肺受量控制在7Gy的单次TBI,是安全、有效的骨髓移植预处理方案。

To investigate the influence of different dose rate on the effect of total body irradiation (TBI).Sixty_seven cases of malignant lymphoma and leukaemia treated with TBI were analyzed retrospectively.From Jul. 1995 to Feb.1999,37 cases (low dose rate group)were used the dose rate of 3.8cGy/min～6.0cGy/min.From Mar. 1999 to Jun.2001,high dose rate was used in 30 cases,among them 10 cGy/min～11.32cGy/min in 29 cases and 22.36 cGy/min in 1 cases.The total dose of TBI was 7Gy～8Gy. BMT was successful with one procedure in all cases.There was no statistic difference in occurrence of complication between two groups.The relapse rate of the high dose rate group was lower than that of the low dose rate group(P<0.05).[Conclusions]Single fraction TBI with the dose rate of 10cGy/min,on which the lung receives the dose under 7Gy is a safe and effective pre_treatment for BMT.