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喉移植的伦理学 被引量:2

Ethical Considerations on Laryngeal Transplantation
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摘要 喉移植的目的在于恢复全喉切除术后患者近似正常的呼吸、吞咽或发音功能 ,并取得最佳的美容效果。但在满足上述条件的同时 ,接受咽喉移植的患者又面临肿瘤复发的可能性增加、排斥反应的发生和长期使用免疫抑制剂所致的免疫功能低下及其诱发的疾病等问题。因为喉是非生命所必需的器官 ,只有当喉移植所获取的利益远远大于其风险时 。 The goals of the larngeal transplantation are the restoration of near normal respiration,phonation,satisfactory deglutition,and the best cosmesis without or with a minimal risk of aspiration.While attaining these benefits,the patient undergoing this procedure must face significant risks,such as a potentially increased probability of cancer recurrence,graft rejection,and the inherent morbidity of chronic immunosuppression.Because larynx is a nonvital organ,laryngeal transplantation is not justifiable or ethical unless the benefit to the patient of having a transplanted larynx is greater than the danger of rejection and the risks of an immunosuppression regimen in a situation that is not life threatening.
出处 《中国医学伦理学》 2002年第1期1-4,共4页 Chinese Medical Ethics
关键词 喉移植 伦理学 原则 喉功能重建 laryngeal transplantation ethics principle
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参考文献9

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同被引文献15

  • 1吕威,张连山,蔡哲,周童亮,李丹.同种异体组织工程化软骨组织形成的初步研究[J].临床耳鼻咽喉科杂志,2004,18(8):485-487. 被引量:4
  • 2秦永.喉移植研究近况[J].中华器官移植杂志,1997,18(1):58-60. 被引量:6
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  • 6Lorenz R R,Hicks D M,Shields R W,et al.Laryngeal nerve function after total laryngeal transplantation.Otolaryngol Head Neck Surg,2004,131:1016-1018.
  • 7Strome S,Sloman-Moll E,Samonte B,et al.Rat model for a vasculariaation for a vascularized laryngeal allograft.Ann Otol Rhinol Laryngol,1992,101:950-953.
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  • 9Jensen J N,Brenner M J,Tung T H,et al.Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine.Ann Plas Sura,2005,54:420-427.
  • 10Nelson M,Fritz M,Dan O,et al.Tacrolimus and mycophenolate mofetil provide effective immunosuppression in rat laryngeal transplantation.Laryngoscope,2003,113:1308-1313.

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