血清降钙素原在颅内感染性疾病中的变化及其临床意义

Application of measurement of serum procalcitonin in meningitis

目的 了解血清降钙素原在颅内感染性疾病中的变化及其临床意义。方法 采用免疫发光测量法 ,对 5 4例颅内感染性疾病患者进行血清降钙素原 (PCT)的测定。结果 化脓性脑膜炎患者急性期PCT显著升高 ,有效的抗生素治疗后迅速下降 ,至恢复期接近正常水平 ;而病毒性脑炎整个病程中PCT水平升高不明显 (P <0 .0 0 1)。结论 PCT测定可作为化脓性脑膜炎和病毒性脑炎早期鉴别诊断的重要依据 ,同时也是判断化脓性脑膜炎治疗效果的客观依据之一。

Objective To investigate serum procalcitonin (PCT) in patients with meningitis.Methods Procalcitonin of 54 patients with meningitis were measured with an immunoluminometric assay.Results Very high levels of PCT correlated with bacterial meningitis,and during antibiotic therapy,PCT decreased rapidly and reached normal levels after recovery.But the PCT levels were low in patients with viral meningitis (P<0.001).Conclusion The measurement of serum PCT may be of value in the differential diagnosis of meningitis due to either bacteria or viruses.