慢性阻塞性肺病时血浆P物质、降钙素基因相关肽与通气功能

Plasma substance P,calcitonin gene-related peptide and ventilation function in COPD patients

目的 通过探讨 P物质 (SP)、降钙素基因相关肽 (CGRP)与肺通功能的相互关系 ,研究 SP和 CGRP在慢性阻塞性肺疾病 (COPD)发病中的作用。方法 采用放射免疫分析法检测缓解期 COPD患者 2 2例 ,健康对照组 2 0例的血浆 SP、CGRP浓度 ,同时检测 COPD组患者的用力呼气一秒量 /用力肺活量 (FEV1 / FVC) ,并分析血浆 SP、CGRP含量与 FEV1 / FVC的相关关系。结果 COPD组患者的血浆 SP浓度 (75.59± 30 .0 1pg/ ml)明显高于对照组 (54.38± 1 1 .51 pg/ ml) (P<0 .0 1 )。COPD组血浆 CGRP浓度 (32 .56± 6.46 pg/ ml)较对照组 (2 9.0 1± 4.0 9pg/ ml)显著升高(P<0 .0 5)。 COPD组患者的血浆 SP、CGRP含量与 FEV1 / FVC呈负相关 (r分别为 - 0 .60 82和 - 0 .581 7,P<0 .0 5)。结论 SP、CGRP可能是COPD发生发展过程中的参与因素。

Objectives To investigate the relation between substance P (SP), calcitonin gene-related peptide (CGRP) and lung ventilation function in order to study the effect of SP and CGRP on the pathogenesis of chronic obstructive pulmonal disease (COPD).Methods 22 COPD patients in remissive period and 20 normal persons as control were enrolled in this study. Plasma SP and CGRP concentration were determined by radioimmunoassay and the FEV1/FVC of COPD patients were measured. The relation between plasma SP, CGRP and FEV1/FVC was analyzed.Results The plasma SP and CGRP of COPD patients increased very significantly comparing with those of the control group. (SP of COPD 75.59±30.01 pg/ml; CGRP of COPD 54.38±11.51 pg/ml), P <0.01 and P <0.05 respectively. The plasma SP and CGRP concentration were negative relevant to FEV1/FVC in COPD patients (r=-0.6082 and r=-0.5817 respectively, P <0.05).Conclusions SP, CGRP may be involved in the pathogenesis of COPD.