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转基因动物模型在毒理学中应用 被引量:1

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摘要 一 从生物医学学科发展上说,21世纪可称为分子生物学世纪.在面向21世纪的预防医学体系中分子毒理学成为此体系中一项重要的内容.
作者 叶常青
出处 《科技和产业》 2002年第2期30-31,共2页 Science Technology and Industry
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  • 1Houdebine LM.Transgenic animal models in biomedical research[J].Methods Mol Biol.2007,360:163-202.
  • 2Vijg J,van Steeg H.Transgenic assays for mutations and cancer:current status and future perspectives[J].Mutat Res.1998,400(1-2):337-354.
  • 3Trimmer PA,Smith TS,Jung AB,et al.Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity[J].Neurodegeneration.1996,5 (3):233-239.
  • 4Wijnhoven SW,van Steeg H.Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis[J].Toxicology.2003,193 (1-2):171-187.
  • 5Rankin TL,Tong ZB,Castle PE,etal.Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding[J].Development.1998,125 (13):2415-2424.
  • 6Kouidhi S,Seugnet I,Decherf S,et al.Peroxisome proliferatoractivated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo[J].Mol Cell Endocrinol.2010,317(1-2):44-52.
  • 7Lofgren S,Baldwin RM,Carleros M.Regulation of human CYP2C18 and CYP2C19 in transgenic mice:influence of castration,testosterone,and growth hormone[J].Drug Metab Dispos.2009,37(7):1505-1512.
  • 8Schober W,Pusch G,Oeder S,et al.Metabolic activation of phenanthrene by human and mouse cytochromes P450 and pharmacokinetics in CYP1A2 knockout mice[J].Chem Biol Interact.2010,183(1):57-66.
  • 9Miksys SL,Cheung C,Gonzalez FJ,et al.Human CYP2D6 and mouse CYP2Ds:organ distribution in a humanized mouse model[J].Drug Metab Dispos.2005,33(10):1495-1502.
  • 10Kathirvel E,Chen P,Morgan K,et al.Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver[J].J Gastroenterol Hepatol.2010,25(6):1136-1143.

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