TGF-β_1在胃癌中表达及意义

The Expression of TGF-β_1 And Its Significance in Human Gastric Cancer

目的 研究TGF - β1在胃癌中表达 ,并评价其临床病理价值。方法 采用免疫组化S -P法研究 ,2 0例正常胃黏膜 ,4 6例胃癌中TGF - β1表达。结果 胃癌组TGF - β1阳性率 10 0 % ,正常胃黏膜组为 5 % ,TGF -β1在胃癌淋巴结转移组表达高于淋巴结无转移组。结论 TGF -

Objective To study the role TGF-β 1 expression in the gastric cancer and to evaluate its clinical and pathological significance.Methods The expression of TGF-β 1 was studied by using S-P immunohistochemical technique in 20 cases of normal gastric tissue and 46 cases of gastric carcinoma.Results in the gastric cancer patients,the positive rate of TGF-β 1 expression was 100%,but there was 50% positive rate in the normal gastric tissues.The TGF-β 1 expression in group with lymph node metastasis was higher than that without lymph node metastasis.Conclusion TGF-β 1 plays an important role in the progress of gastric cancer.