泌乳素受体与乳腺癌预后因素的相关性研究

Relationship between Prolactin Receptor and Prognostic Factors in Breast Cancer

目的:探讨PRL-R对估计乳腺癌预后的临床价值。方法:采用放射配基结合分析法和放射免疫分析法,测定乳腺癌组织中PRL-R含量及血清PRL水平,分析PRL-R阳性率(RT≥20fmol/mg·蛋白为阳性)与乳腺癌临床、病理系列预后指标的相关性。结果:92例乳腺癌中,PRL-R阳性率为50%,其与乳腺癌肿块大小、组织学分级、腋淋巴结转移及临床分期有显著性相关(均P<0.05)。其中淋巴结转移1～3个者较无转移者PRL-R阳性率均显著增高(均P<0.05)。PRL-R阳性率与患者年龄、月经状况、癌肿病理类型及血清PRL含量未见显著相关(均P>0.05)。结论:PRL-R阳性与人体乳腺癌不良预后因素有关。

Objective:To assess the prognostic values of PRL-R in primary breast cancer.Methods:The binding sites of PRL-R(92cases)and serum PRL content (73cases)were sepa-rately determined with radioligand binding assay of receptor and radioimmunoassay.PRL-R levels of20fmol/mg protein or higher were regarded as the receptor positive.The correlation of PRL-R and clinical prognostic factors of breast cancer was studied.Results:The PRL-R positive rate was50%in primary breast cancer.It was closely correlated to histologic grading,lymph node involvement,clinical staging and tumor size(P<0.05).Furthermore,the incidence of the receptor positive tumor was higher in1-3involved lymph nodes than in no involved lymph nodes(P<0.05).No correlation was detected between positive rate of PRL-R and patient's age,menopause,pathological type and PRL content.Conclusion:Patients with positive PRL-R showed poor prognosis.The PRL-R probably predict the early prognosis of breast cancer.