阿尔茨海默病与脑血管性痴呆的诱发电位比较

A comparative study of brain evoked potentials among Alzheimers disease and vascular dementia

目的 :探讨阿尔茨海默痴呆 (AD)和脑血管性痴呆 (VD)的诱发电位特点。方法 :收集 2 5例AD组、2 4例VD组及 2 2名正常老年人 (NC) ,完成听觉诱发电位 (AEP)和视觉诱发电位 (VEP)检查。结果 :AD组和VD组及NC组在潜伏期AEP/N1、P2 ,VEP/P1,波幅AEP/P2、P3,VEP/P2、P3上有显著性差异 (P <0 0 5～ 0 0 1)。与NC组相比 ,AD组潜伏期AEP/N1、P2 ,VEP/P1延迟 ,波幅AEP/P2、P3,VEP/P2、P3降低。与NC组相比 ,VD组在潜伏期VEP/P1延迟 ,波幅P2、P3降低。AD组与VD组相比 ,在潜伏期AEP/N1、N2上有显著差异 ,AD组延迟于VD组。AD组VEP的P1潜伏期 ,VD组AEP的P3波幅及VEP的N1潜伏期改变上与其MMSE评分有关联。结论 :AD组与VD组的诱发电位变化有类似的异常 ,但AD组病损范围广 ,经不同感觉系统诱发的脑诱发电位均有异常。两组痴呆中的三个指标与MMSE关联的特点 。

Objective:The characteristics of BEPs were investigaed among AD and VD.Methods:Auditory and visual EPs were acquired from 25 AD patients , 24 VD patients and 22 matched conrol subjects.Mini mental state examination(MMSE) was used to obtain cognitive function ratios in patients.Results:A significant different of BEPs among three groups was found with both latencies(AEP/N1?P2 and VEP/P1)and amplitudes(AEP/P2?P3 and VEP/p2?p3)(P<0 05 or 0.01).Compared with control group,AD group exhibited the prolonged latencies(AEP/N1?P2 and VEP/p1) and the reduced ampitudes(AEP/P2?P3 AND VEP/P2?P3);while VD group showed the prolonged latencies(VEP/P1)and ampilitudes(VEP/p2?p3). The prolonged latencies(AEP/N1?P2)displayed significantly longer than in VD groups.Both latencies(VEP/P3 in AD group and VEP/N1 in VD group)and amplitudes(AEP/P3 in AD in group) correlated with patient' MMSE scores.Conclusion:VD group showed the similar abnormalities in BEPs as compared to AD group,but the later had more extensive brain impairment.The associations of N1?P2?N3 with MMSE scores deserve further studing.