摘要
目的 探讨晚期血吸虫病巨脾切除对免疫功能的影响。方法 对 2 0例晚期血吸虫病巨脾病人切除前、术后两周、术后半年、术后一年分别抽取周围静脉血测IgG ,IgA ,IgM ,C3 ,C4 ,TNF ,sIL 2R ,CD3+ ,CD4+ ,CD8+ ,用F检验作出显著性测定。结果 IgA ,IgM ,C3 ,C4 ,TNF ,sIL 2R ,CD8+ 切脾前后差异不显著 (P >0 0 5 ) ,IgG ,CD3+ ,CD4+ ,CD4+ /CD8+ 切脾后升高 ,差异显著 (P <0 0 1~ 0 0 5 )。结论 晚期血吸虫病巨脾切除后对体液免疫和细胞免疫均无不良影响 ,因而治疗性脾切除是合理的。
Objective To investigate influence of splenectomy on immune function of patients with advanced schistosomiasis. Methods Before and 2 weeks after the splenectomy, levels of IgG, IgA, IgM, C 3, C 4, TNF, sIL 2R, CD4 + and CD4 +/CD8 + in peripheral venous blood were determined in 20 patients with advance schistosomiasis. The follow up was conducted for 6 months to 1 year. Results The levels of IgG, CD3 +, CD4 + and CD4 +/CD8 + after the operation were significantly higher than those before the operation (P<0 01-0 05). As for other indexes, there were no remarkable differences between the preoperative level and the postoperative one (P>0 05). Conclusions In patients with advanced schistosomiasis, splenectomy has no significant effects on humoral and cellular immunity. Therefore, it is reasonable to use this technique in treatment of advanced schistosomiasis.
出处
《中华肝胆外科杂志》
CAS
CSCD
2002年第1期31-33,共3页
Chinese Journal of Hepatobiliary Surgery
关键词
血吸虫病
脾肿大
脾切除术
免疫功能
Schistosomiasis
Splenomegaly
Splenectomy
Immune function