选择性IgA缺乏症的免疫学和临床表现(附28例报告)

The immunological and clinical manifestation of selective IgA deficiency

目的 :探讨选择性IgA缺乏症 (SelectiveIgADeficiency ,SIgAD)病人的发病规律及免疫学、临床表现。方法 :以单向免疫扩散法及酶联免疫吸附试验测定血清IgG、IgA、IgM、IgE ,以间接免疫荧光法检测抗核抗体 ,以PHA淋巴细胞转化试验形态学检查法测定细胞免疫功能。结果 :2 8例患者血清IgA低于 0 1g L ,且IgG、IgA、IgM、IgE基本正常 ;4 0 91%的SIgAD患者血清抗核抗体阳性 ;6 6 6 7%的患者淋巴细胞转化率低于正常 ;临床表现主要以自身免疫性疾病最为多见 ,呼吸道感染、消化系统疾病次之。结论 :SIgAD患者常伴有其他免疫学检查的异常 ,临床上易合并自身免疫病。

Objective:In view of the immunological and clinical manifestation of SIgAD.Methods:Single radial immunodiffusion technique was emploied to determine serum IgG?IgA?IgM and the enzyme linked immunosorbent assay(ELISA) had been used to measure serum IgE;anti unclear antibodies(ANA) were test with indirect immunofluorescence technique,cellular immunity was test with lymphocyte translation assay.Results:Tweenty eight patients with selective IgA deficiency were seen during the last tween years(IgA<1 g/L),all with normal levels of IgG?IgM and IgE.Of which about 40 91% were anti nucler antibodies(ANA) positive and about 66.67% had a low rate of lymphocyte translation.The chief clinical manifestation were those of autoimmune disease,respiratory tract infections and disease of digestive system were also frequently noted.Conclusion:Selective IgA deficiency was often along with the other abnormit.It is often combined with auto immune disease.