血清乙肝病毒标志物和循环免疫复合物间关系

The Relationship of Serumal HBV Marker with Circulating Immune Complexes

目的 探讨乙型肝炎患者血清 HBV抗原抗体标志物和 HBs Ag特异及非特异性循环免疫复合物间的关系。方法 2 0 5份血清 ,用 PEG沉淀法检测 CIC,ELISA检测 HBVM、HBs- CIC、HBs Ag/ C3 - TCIC、Ig G/ C3 - TCIC,免疫比浊法检测 Ig G和 C4 。结果 1乙肝病毒感染过程中半数以上有 HBs Ag特异性的循环免疫复合物形成 ,HBs Ag阳性特别是同时伴有 HBe Ag阳性时 ,血清各类 CIC阳性率及 Ig G水平均显著增高 ,C4 水平显著下降。2 HBs Ag阴性、抗 HBs阳性血清中 ,各类 CIC仍有 1 3 %～ 2 1 .7%的阳性率。结论 乙肝病毒血清标志物的存在及模式与 HBs Ag特异及非特异性循环免疫复合物的形成有关。

Objective To probe the relationship of serumal HBVM with HBsAg-special/nonspecial-circulating immune complexes.Methods In 205 sera,HBVM,HBs-CIC were detected by ELISA;HBsAg/C_3-TCIC and IgG/C_3-TCIC were detected by anti-C_3 capture ELISA;CIC were detected by PEG sedimentary procedure;IgG and C_4 were detected by immunoturbidimetry.Results ① HBsAg-special-circulating immune complexes formed in more than half of hepatitis B virus infection.The CIC,HBs-CIC,HBsAg/C_3-TCIC and IgG/C_3-TCIC positive rates and the concentration of IgG increased.but C_4 dropped in HBsAg positive sera.especially HBsAg and HBeAg positive sera.② In HBsAg-negative and anti-HBs positive sera,the four types CIC positive rates reached 13%～21.7%.Conclusion HBVM and it's pattern in serum are associated with the formation of HBsAg-special/nonspecial-circulating immune complexes.