偏头痛患者血浆与脑脊液中NO含量变化的临床意义

Changes of Nitrogen Oxide in blood and cerebrospinal fluid of the patient with migraine

目的 探讨偏头痛患者血浆、脑脊液中一氧化氮 (NO)含量在发病机制中的作用。方法 采用分光光度法对偏头痛发作期的 46例患者 ,偏头痛间歇期的 42例患者以及 41例健康对照者分别测定其颈静脉血、肘静脉血及部分脑脊液中NO含量并进行比较分析。结果 (1)偏头痛发作组患者颈静脉血浆、脑脊液中NO含量与偏头痛间歇组、对照组相比差异有显著性意义 (P <0 0 1)。 (2 )偏头痛发作组、间歇组患者肘静脉血浆NO含量与对照组的比较 ,差异无显著性意义 (P >0 0 5 )。结论 NO与偏头痛发作有密切关系 ,应用NO合成酶抑制剂有助于偏头痛的治疗。

Objective To study the effect of Nitrogen Oxide (NO)content in blood plasma and cerebrospinal fluid of patients with migraine on pathologic mechanism.Methods The NO content of jugular blood,cubital venous blood and cerebrospinal fluid were determined respectively with spectrophotometric method among 46 cases in the stage of attack,42 cases in the intermission and 41 cases in the control group.Results (1)The NO content of jugular blood and cerebrospinal fluid in the stage of attack increased much more than that of the intermission group and the control group(P<0 01),there was obvious difference.(2)There was no marked difference in the NO content of cubital venous blood plasma among the three groups(P>0 05).Conclusion The NO is closely related to the attack of migraine,and NO synthetase depressor can help the treatment of it.