急性有机磷农药中毒患者血浆内皮素的变化及临床意义

The clinical significance of plasma endothelin measurement in acute organophosphorus pesticide poisoning

目的 探讨急性有机磷农药中毒 (AOPP)患者血浆内皮素 (ET)的变化及其临床意义。方法 将 6 9例AOPP患者分成轻度、中度、重度中毒组 3组 ,另选取 2 5例健康人为正常对照组 ,各组均采用放射免疫法检测血浆ET含量。同时进行对比分析。结果 AOPP轻度中毒组患者血浆ET的含量 (5 6 18± 12 80 )ng/L仅轻度升高 ,与正常对照 (5 0 85± 8 93)ng/L比较 ,差异无显著性 (P >0 0 5 ) ;中度、重度中毒组患者血浆ET含量分别为 :(72 6 1± 14 2 1)ng/L ,(110 32± 17 38)ng/L较正常对照组明显升高 (P均 <0 0 1) ,中度中毒组患者血浆ET含量较轻度中毒组明显升高 (P <0 0 1) ;重度中毒组患者血浆ET含量较中度中毒组明显升高 (P <0 0 1)。结论 随着AOPP中毒程度的加重 ,血浆ET含量逐渐上升 ,血浆ET的检测可作为判断AOPP患者病情轻重。

Objective To investigate the clinical significance of plasma endothelin (ET) contents in patients with acute organophosphorus pesticide poisoning (AOPP).Methods 69 cases of AOPP were divided into 3 groups: mild poisoning , moderate poisoning and severe poisoning groups. 25 healthy subjects served as controls. The contents of plasma ET of the patients and healthy subjects were determined.Results No significant difference was noted between the contents of plasma ET of the control and the mild group (50.85±8.93) ng/L vs (56.18±12.80) ng/L,P>0.05. The contents of plasma ET of mild cases were only slightly increased. The contents of plasma ET in the moderate (72.61±14.21 ng/L) and serve group (110.32±17.38 ng/L) were significantly higher than those of the control group (P<0.01,P<0.01). The contents of plasma ET in the moderate were significantly higher than those of the mild group (P<0.01). The contents of plasma ET in the serve group were significantly higher than those of the moderate (P<0.01). Conclusion With the increase of AOPP severity, the contents of plasma ET elevated gradually . Plasma ET may serve as an important index for the clinical course , therapeutic efficacy and prognosis of AOPP. Early regression of the contents of plasma ET may play an active role in preventing and curing multiple system organ failure resulted from AOPP and in improving the prognosis.