高通量药物筛选技术进展与新药开发策略

Strategy of drug development and application of high throughput screening

高通量药物筛选技术的快速发展 ,促进了高新技术和科学研究成果在医药科学研究中的广泛应用。生命科学技术、化学以及计算机技术的快速发展 ,在新药研究与开发中提出了大量新的课题 ,极大地促进医药研究的进程。但新技术的应用 ,必须及时调整研究策略 ,才能真正发挥新技术的作用。本文讨论了计算机技术、生物芯片技术、组合化学合成技术、组合生物合成技术以及高通量筛选技术在药物发现中的作用和特点 ,探讨了新的药物发现的规律和特点 ,提出新技术应用条件下药物发现的基本策略。

Application of new techniques such as biochip, combinatorial chemistry, combinatorial biosynthesis computer etc in high throughput screening, has been promoted the procedure of new drug development. In present paper, the development of high throughput screening is reviewed and several important new techniques are introduced in briefly. Depend on the characteristics of new drug discovery system, the new strategy of drug discovery and drug development are discussed.