雷公藤榕碱的结构与分离

ISOLATION AND STRUCTURE OF WILFORDLONGING FROM TRIPTERYGIUM WILFORDII HOOK .F.

目的 研究雷公藤 (TripterygiumwilfordiiHook .f.)的化学成分。方法 应用各种色谱技术进行分离纯化 ,用UV ,IR ,MS ,HRMS ,1 HNMR ,1 3CNMR(COM和OFR) ,1 H 1 HCOSY ,1 H 1 3CCOSY ,2D NOESY ,1 H 1 3CCOLOC鉴定化合物的结构。结果 分离并鉴定了 2个生物碱 :I为wilforgine ,II为雷公藤榕碱 (wilfordlongine)。

AIM To study the chemical composition of Tripterygirm wilfordii Hook.f. METHODS Colunm chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR , 13 CNMR (COM and OFR), 1H 1H COSY, 1H 13 C COSY, NOESY and COLOC spectra were used to determine the structures of the isolated constituents. RESULTS Two sesquiterpene alkaloids were isolated and their structures were elucidated as wilforgine and wilfordlongine on the basis of spectral evidence. CONCLUSION Wilfordclonine is a new sesquiterpene alkaloid.