人早孕期蜕膜组织中细胞的组织化学与免疫组织化学研究

The Study of Histochemistry and Immunohistochemistry of the Cells in the Early Human Pregnancy Decidual Tissue

用组织化学及免疫组织化学方法证明了早孕期蜕膜组织中的细胞的种类.以形态大小可分两类,大细胞及小细胞.大多数大细胞含有丰富的糖原及脂滴,小细胞不含糖原及脂滴,但含玫瑰红颗粒.用免疫组织化学方法,鼠抗人 T_1、T_2及 T_3单克隆抗体,显示早孕期蜕膜中的细胞,只见极少淋巴细胞;用鼠抗人巨噬细胞,鼠抗人 HLA-DR 阳性细胞单克隆抗体显示蜕膜组织中的细胞,发现较多巨噬细胞及 HLA-DR 阳性细胞.它们位于大细胞之间.这些结果支持小细胞是抑制细胞,能抑制淋巴细胞的增殖及其免疫活性,利于胚泡植入和不被排斥.同时也证明在大细胞中有较多巨噬细胞与 HLA-DR 阳性细胞.

There were more kinds of cells in the early human pregnancy decidual tissue.It may be difficult to distingush these cells into classes with HE stain.Two kinds of cells,big and small,were identified.Big cells contained rich glycogen and lipid,while small cells did not contain them.With immunohistochemical stain,We have found a lot of macrophages and HLA-DR positive cells.However,T lymphocytes were scarce.This study supported the view that small cells were suppressor cells.They suppressed the proliferation and immunocom- peteace of T lymphocytes.Because of the suppression of T lymphocytes, blastocytes could be immplanted and embryos could not be rejected from maternal decidua.