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2型糖尿病的病因遗传学研究进展 被引量：3

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摘要 目前对胰岛素抵抗的分子遗传学方面研究主要涉及“节俭基因”的后选基因,包括β2-和β3肾上腺素能受体、脂蛋白脂肪酶、激素敏感脂肪酶、胰岛素受体及其底物、糖原合成酶、过氧化物酶增殖体激活受体-γ基因等。而胰岛β细胞功能缺陷方面的遗传基因异常主要涉及葡萄糖转运子-2、ATP敏感的K+通道异常、前胰岛素和胰岛素基因异常的基因突变,以及胰岛淀粉样蛋白在胰岛β细胞内沉积等。
作者 田浩明
机构地区 四川大学华西医院内分泌科
出处 《国外医学（内分泌学分册）》 2002年第2期78-81,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 2型糖尿病 胰岛素抵抗 胰岛Β细胞功能缺陷 基因突变 病因 遗传学 研究进展
分类号 R587.1 [医药卫生—内分泌]
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参考文献18

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同被引文献30

  • 1周智广,李霞.成人隐匿性自身免疫糖尿病研究的新进展[J].中国医学科学院学报,2003,25(5):630-634. 被引量：13
  • 2Ahren B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. Clin Endocrinol Metab, 2004, 89(5): 2078-2084
  • 3Zimmet P,Shaw J, Albertit KG. Preventing type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic view. Diabet Med, 2003, 20(9): 693-702
  • 4Wiseman, Alexander, Ronald. Current status of clinical islet transplantation: advances and obstacles. Curr Opin Endocrinol Diabetes, 2004, 11(2): 98-103
  • 5Zhang Y, Atkinson. Gene therapy for type 1 diabetes: metabolism, immunity, islet cell preservation, and regeneration. Curr Opin Endocrinol Diabetes, 2004, 11(2): 91-97
  • 6Bloomgarden ZT. Type 2 diabetes in the young. Diabetes Care, 2004, 27(4): 998-1010
  • 7Engelgau MM. Diabetes diagnostic criteria and impaired Glycemic states: evolving evidence base. Clin Diabetes, 2004, 22(2): 69-70
  • 8Gura T. Diabetes research: new lead found to a possible ""insulin pill"". Science, 1999, 284(5416): 886
  • 9Barnett AH. A review of basal insulins. Diabet Med, 2003, 20(11): 873-885
  • 10Cefalu WT. Concept, strategies, and feasibility of noninvasive insulin delivery. Diabetes Care, 2004, 27(1): 239-246

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国外医学（内分泌学分册）
2002年 第2期

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