摘要
用从银耳中提取的多糖和 FeCl_3为主要原料合成一种新的补铁剂——银耳多糖铁(Ⅲ)配合物(ITC),并测定了其理化性质。实验证明:在 ITC 水溶液中,不存在游离 Fe^(3+),表明铁(Ⅲ)与银耳多糖形成了稳定的配合物.经红外光谱、超速离心及电镜观测可知:银耳多糖铁(Ⅲ)配合物是以β-(FeOOH)。为微核,银耳多糖在其核表面络合而形成的表面配合物,其粒子直径约为30~80 nm,属于高分子化合物。ITC 在生理 pH 下不沉淀、不水解,可望有较好的生物利用度.
A new kind of iron-supplementary drug——iron(Ⅲ)-tremella fuciformis polysaccha- ride complex(ITC)was synthesized with FeCl_3 and tremella fuciformis.Because it was not free Fe^(3+)in the ITC solution,therefore this complex was very stabe.The investigation by infrared spectra,ultracentrifugation and electron microscopy showed that structure of ITC was an interracial compex with β-(FeOOH).core and a high polymer.The diameters of complex particles ranged from 30~80 nm.Because it was not precipitated and dissociated at the physiological pH it higher bioavailability would be expected.
关键词
铁
补铁剂
多糖铁
银耳
配合物
iron
iron-supplementary
iron(Ⅲ)-polysaccharide complex