血清孕酮水平对体外受精胚胎移植结局的影响

Impact of Serum Progesterone Levels on Clinical Outcome of in Vitro Fertilization and Embryo Transfer

【目的】探讨注射人绒毛膜促性腺激素 (HCG)日血清孕酮水平对体外受精与胚胎移植 (IVF ET)结局的影响。【方法】回顾分析 2 0 0 0年 2月至 2 0 0 1年 1月 947个IVF ET周期的资料。【结果】在控制性超排卵中 ,按注射HCG日血清孕酮浓度不同分 3组 ,依次为≤ 2 86nmol/L(0 9ng/mL)组、>2 86nmol/L～≤ 9 5 4nmol/L(3ng/mL)组、>9 5 4nmol/L组 ,IVF ET的种植率分别为 2 2 2 0 %、19 75 %、11 83%,临床妊娠率分别为 45 91%、42 4 0 %、2 6 5 3%。孕酮 >9 5 4nmol/L组的种植率及临床妊娠率比其它组低 ,经 χ2 检验 ,有统计学意义。【结论】HCG注射日血清孕酮明显升高时 ,IVF ET的种植率及临床妊娠率明显下降。

Objective To evaluate the impact of serum progesterone concentration on the day of human chorionic gonadotropin (HCG) administration on clinical outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods 947cycles of IVF-ET performed in Reproductive Medical Center of the First Affiliated Hospital, Sun Yat-sen University of Medical Sciences from February 2000 to January 2001 were analyzed retrospectively. Results Patients were divided into three groups according to serum progesterone levels ≤2.86 nmol/L(0.9 ng/mL)?>2.86 nmol/L～≤9.54 nmol/L(3 ng/mL)?>9.54 nmol/L on the day of HCG administration. Implantation rate was 22.20%, 19.75% and 11.83% respectively and pregnancy rate (PR) was 45.91%, 42.40% and 26.53% respectively in this 3 groups. Comparing with other groups, the implantation rate and PR were low in progesterone >9.54 nmol/L group. The difference was statistically significant. Conclusion Implantation rate and clinical pregnancy rate significantly decrease when serum progesterone levels on the day of HCG administration dramatically increase.