儿童汉语阅读障碍的脑血流与阅读技能研究

The correlative analysis between CBF measured by SPECT and Chinese reading test in childhood reading disorder

目的 探讨儿童汉语阅读障碍 (RD)的脑血流改变与阅读技能诊断测试 (CRSDT)评分的关系。方法 用非采血法SPECT显像测定 2 5例RD患儿和 2 0例正常对照者全脑血流量 (CBF)、左右脑血流量及局部脑血流量 (rCBF)。CRSDT测得阅读技能总粗分 (TRS) ,并分析TRS与CBF间的关系。结果 患儿组CBF为 (38.87± 3.77)mL·10 0g- 1 ·min- 1 ,明显低于对照组 [(4 3.6 5± 2 6 4)mL·10 0g- 1 ·min- 1 ,P <0 .0 1],患儿rCBF显著降低区域分布频率为额叶、枕叶 >顶枕交界区 >颞叶 >顶叶 >丘脑>其他 (小脑、脑干、基底节 ) ,RD组TRS与CBF呈明显正相关 (r为 0 .6 5 1,P <0 0 5 )。结论 RD儿童存在脑血流代谢降低 ,SPECT脑血流显像及定量测定能够客观评价其病变的严重程度。

Objective To investigate changes of cerebral blood flow (CBF) and its association with Chinese reading skill diagnostic test (CRSDT) in childhood reading disorder (RD). Methods In 25 RD children and 20 age-matched control subjects, we quantitatively determined CBF and regional cerebral blood flow (rCBF) with SPECT using the non-blood-withdrew method. We studied the correlation between the CBF and the total raw scores by CRSDT. Results CBF in case group was (38.87±3.77) mL·100 g -1 ·min -1 and was significantly lower than that in control group[(43.65±2.64) mL·100 g -1 ·min -1 ( P <0.01)]. These reduction in CBF correlated with the total raw scores by CRSDT. Conclusion These results suggest the children with reading disorder have CBF reduction and SPECT is useful for evaluation of cerebral functioning in reading disorder children.