新生儿缺氧缺血性脑病SPECT显像研究

The study on ^(99)Tc^m-ECD SPECT regional cerebral blood flow imaging in neonatal hypoxic-ischemic encephalopathy

目的 探讨新生儿缺氧缺血性脑病SPECT显像的特点。方法 对 30例符合新生儿缺氧缺血性脑病诊断和分度标准的患儿和 10例正常新生儿进行SPECT脑血流灌注断层显像 ,并与CT、MRI进行比较。结果 2 2例同时做SPECT、CT和MRI的患儿中 ,轻度组 7例 ,SPECT、CT和MRI阳性数分别为 7例、3例和 5例 ;中度组 10例中 ,3种方法的阳性数分别为 10例、8例和 9例 ;重度组 5例 ,3种方法均为阳性 ;SPECT、CT和MRI总的阳性检出率分别为 10 0 %、72 7%和 86 4%。结论 SPECT显像是诊断该病较灵敏的方法 ,与CT、MRI结合能对脑组织的生理、病理及代谢、功能状态作出诊断。

Objective To investigate the imaging characteristics and the value of 99 Tc m-ethylene cysteinate dimer (ECD) SPECT regional cerebral blood flow (rCBF) imaging in neonatal hypoxic-ischemic encephalopathy (HIE) and to compare with CT,MRI. Methods Thirty patients with neonatal HIE and 10 normal neonates underwent 99 Tc m-ECD SPECT rCBF imaging. And in 22 of the 30 patients,the results were compared with that of CT,MRI. Results For the 22 patients who underwent SPECT,CT and MRI,the total positive rates of the three modalities were 100%,72.7% and 86.4%. Conclusions 99 Tc m-ECD SPECT rCBF imaging is a sensitive method for diagnosis of neonatal HIE and it may reflect clinical stage of the disease. If 99 Tc m-ECD SPECT rCBF imaging combined with CT, MRI together,not only can diagnose cerebral physiological functions,pathologic picture,but also can diagnose cerebral metabolism and functioning. The method is very significant to clinial diagnosis and curative effect.