^(131)I胶囊和液体在家兔及人体代谢的对比研究

Comparison of thyroid uptake of ^(131)I capsule and solution in rabbits and Graves disease patients

目的 观察1 3 1 I胶囊和液体在家兔和甲亢患者甲状腺吸1 3 1 I率 (TUR)的异同 ,建立测量1 3 1 I胶囊TUR的方法。方法 ①家兔实验。 6只家兔随机分为胶囊组和液体组 (均予 7 4MBq1 3 1 I)。行γ显像 ,计算TUR。②甲亢患者1 3 1 I胶囊标准源测量。 10 4例Graves甲亢患者 ,1 3 1 I示踪和治疗剂量均采用胶囊给药 ,与均采用液体给药的 118例患者进行治疗前后 2 4hTUR比较。结果 ①家兔甲状腺对1 3 1 I胶囊和液体的 2 ,4,6 ,2 4hTUR均无差异。②1 3 1 I胶囊标准源测量 :溶解计数较胶囊直接测量高 (13 8± 2 8) % ,t=8 97,P <0 0 1。③甲亢患者胶囊组示踪剂量TUR为 (71 4± 10 9) % ,治疗剂量TUR为 (6 8 5± 14 7) % (t =1 6 2 ,P >0 0 5 ) ;液体组分别为 (71 3± 12 3) %和 (6 5 1± 13 0 ) % (t =3 82 ,P <0 0 1)。示踪剂量 2 4hTUR在 80 0 %以上者 ,2组治疗剂量平均TUR均低于示踪剂量。结论 ①家兔对1 3 1 I胶囊各时相TUR与液体比较无差异。②1 3 1 I胶囊做标准源须溶解于甲状腺模型内。③胶囊剂型可以作为1 3 1 I治疗甲亢的标准方法。④示踪量TUR 80 0 %以上者 2组示踪剂量TUR均高于治疗量TUR ,注意加大1 3 1 I投予量。

Objective To observe the difference between thyroid uptake rates (TUR) of 131 I capsule and solution in rabbits and Graves disease patients. Methods Part one:6 rabbits randomized into two groups received capsule or solution of 131 I 7.4 MBq.Then with SPECT scintigraphy 2,4,6 and 24 h thyroid pure counts in percentage of stomach counts(first frame) were determined. Part two:①Measured 131 I capsule standard. ②104 patients with Graves disease were administered tracing and therapeutic dose of 131 I capsule(capsule group),118 of 131 I solution(solution group). Compared the tracing and therapeutic 131 I TUR at 24 h. Results Part one: There were no significant difference at 2,4,6,24 h TUR between capsule and solution group. For 1 case the maximum TUR was at 6 h in capsule group and 2 cases in solution groups. Part two:①For the 131 I capsule administered immediately after being dissolved in 30 mL of water, the activity counts measured were higher by (13.8±2.8)% than it was administered directly, t=8.97, P< 0.01. ②24 h TUR in capsule group for tracing and therapeutic dose were (71.4±10.9)% and (68.5±14.7)%( t=0.86,P >0.05) and in solution group were(71.3±12.3)% and (65.1±13.0)%( t=3.82,P <0.01), respectively. The therapeutic TURs were lower than tracer TUR while the later was higher than 80.0% in both groups. Conclusions ①There was no difference in TURs between capsule and solution formulations in rabbits.② 131 I capsule standard should be dissolved before being measured. ③ 131 I capsules can be used as a standard formulation for Graves disease patients.④The dose of 131 I should be increased as tracer TUR is larger than 80.0%.