卵巢早衰与自然绝经妇女骨密度的对比观察

Comparison of BMD between women with premature ovarian failure and natural menopausal women

目的 比较卵巢早衰 (POF)与自然绝经妇女的骨密度 (BMD)。方法 6 3例经DEXA确诊为骨质疏松的病人分为两组 :2 9例POF为A组 ,年龄 4 8～ 76岁 (6 2 1± 7 0 ) ;34例自然绝经妇女为B组 ,年龄 5 2～ 77岁 (6 3 4± 6 0 )。应用美国Hologic公司QDR4 5 0 0 W型双能X线骨密度仪测定A组和B组腰椎及股骨颈BMD。结果 A、B两组腰椎 2 4、股骨颈BMD相比 ,有显著性差异 (P <0 0 5 )。结论 POF比自然绝经妇女骨量丢失的早并且丢失的多 ,应及早应用HRT。

Objective\ To investigate the differences in bone mineral density(BMD) between women with premature ovarian failure(POF) and natural menopausal women. Methods\ Sixty three women diagnosed as having osteoporsis were divided into two groups:group A consisted of 29 cases of POF, aged 48 76(62±7 0);group B consisted of 34 natural menopausal women, aged 52 77 (63 4±6 0). Dual energy X ray absorptiometer (Hologic, QDR 4500 W) was used to determine the BMD of lumbar vertebrae(2 4) and femoral neck in groups A and B. Results\ There were significant differences in BMD of L2 4 and femoral neck between group A and group B( P <0 05). Conclusion\ Bone loss occurs early in women with POF and is more severe than that in natural menopausal women.Hormone replacement therapy should be used as early as possible.