化疗加栓塞治疗原发性肝癌的疗效观察

Observation on therapeutic effects of chemotherapy and embolization in primary hepatocellular carcinoma

目的探讨化疗加栓塞对原发性肝癌的疗效。方法70例原发性肝癌患者随机分为治疗组(n=45)和对照组(n=25)。全部病人均经导管灌注化疗药物,治疗组追加肿瘤供血动脉栓塞。治疗后,全部病人经随访观察1～3年。结果治疗组疗效明显优于对照组,患者生存期明显延长,且两组间有统计学上的显著差(P<0.05)。结论化疗加栓塞是原发性肝癌非手术治疗的首选方法。

Objective To explore therapeutic effect of chemotherapy and embolization in primary hepatocellular carcinoma(PHCC). Methods 70 patients with PHCC were randomly divided into treatment group (n=45) and control group (n=25).All patients underwent transcatheter intra-artery infusion of chemotherapcutic agents(ADM.5Fu.MMC),45 in treatment group underwent additional transcatheter hepatic artery embolization(mixture of lipiodol and ADM).After the treatment,all patients were followed-up for 1-3 years.Results Better therapeutic effects and longer survival term were found in treatment group and there is a statistic difference between both groups(p < 0.05).Conclusion Chemotherapy plus embolization is an optimal choice of non-surgical treatment for PHCC.