摘要
在糖尿病患者体内以及衰老进程中晚期糖基化终末产物 (AGEs)是不断积累的 ,其可以通过直接或间接的方式对机体产生病理作用。本文概述了AGEs对各种组织或细胞包括心血管组织、肾脏、大脑和骨组织等的间接病理作用和机制、介导该作用的AGEs受体或其他结合蛋白 。
Advanced glycation endproducts (AGEs) always accumulate in diabetic patients and senile people, which can cause pathological actions to the whole body in direct and indirect way.This article reviews the indirect pathological actions and mechanism of AGEs to various tissues and cells,including cardiovascular tissue,kidney,brain and bones,etc.,the AGEs receptor and other AGEs binding proteins that mediates this action and inhibitors that inhibit the formation and action of AGEs.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第2期113-116,共4页
Chinese Journal of New Drugs
基金
国家重点基础研究发展规划资助项目 (G2 0 0 0 0 5 70 10 )
