曲唑酮治疗68例广泛性焦虑症的临床观察

A study of trazodone in the treatment of 68 cases general anxiety disorder

目的 :观察曲唑酮治疗广泛性焦虑症的临床疗效和不良反应。方法 :对 6 8例广泛性焦虑症患者给予曲唑酮治疗 ,初始剂量为 5 0mg·d-1,隔 2～ 3d增加 5 0mg·d-1,1周内加至治疗量 (5 0～ 2 0 0mg·d-1) ,疗程 4周 ;采用自制的调查表格、汉密尔顿焦虑量表 (HAMA)、焦虑自评量表 (SAS)评价疗效 ,不良反应量表 (TESS)评价不良反应。结果 :曲唑酮治疗焦虑的有效率为 91.17% ,痊愈率为 6 6 .17% ,并且有 4 8.5 3%的患者的自觉性功能改善 ,研究过程中未发现明显心血管不良反应 ,其他主要是一些轻度的抗胆碱能不良反应。结论 :曲唑酮可作为一种新型高效、安全的抗焦虑剂 ,尤适用于伴有性功能障碍的患者及老年患者。

Objective:To estimate the therapeutic effect and side effect of trazodone in the treatment of general anxiety disorder(GAD).Methods:68 patients with GAD were assigned to receive daily 50～200mg trazodone for four weeks.Effects and side reactions were evaluated with Hamilton Anxiety Scale(HAMA),Self Rating Anxiety Scale(SAS), Self made investigation and Treatment Emergent Symptoms Scale(TESS) before and after treatment.Results:Trazodone was effective in the treatment of GAD, produced slight side effects and prompted sexuality.Conclusion:Trazodone may be a novel,safe and effective anti anxiety and suitable in treatment of old and unsexual patients. [