中国围生儿小头畸形的调查研究

The epidemiological characteristics of microcephaly in China

目的 :了解小头畸形在中国的发生状况及其围生儿的围生期特点。方法 :1987～ 1992年中国出生缺陷监测网以医院为基础在全国对孕 2 8周～产后 7天围生儿监测 ,对 2 84例小头畸形围生儿进行流行病学分析。结果 :5年共监测围生儿 44 89692例 ,小头畸形儿 2 84例。中国小头畸形发生率为 0 .63/万 ,女性发生率为 0 .73/万 ,男性为 0 .5 1/万 ;城镇为 0 .5 8/万 ,农村为 0 .73/万。 47.2 %的小头畸形围生儿为低体质量儿。围生期病死率为 60 .2 %。结论 :我国小头畸形的发生率与其他国家相似 ,女性高于男性。其围生儿素质较差 ,围生期病死率较高。

Objective:It is to study the status and the perinatal characteristics of microcephaly in China. Methods: From 1987 to 1992, the data of microcephaly cases were collected from hospital-based units involved in monitoring program. The monitored subjects were the hospitalized births from 28 weeks gestation to the 7th days after delivery.Results: There were 4489692 births and 284 microcephaly cases in China with an incidence rate of 0.63/10000 during the period from 1987 to 1992. The incidence in males was 0.51/10000, and 0.73/10000 in females. It was 0.58/10 000 and 0.73/10 000 respectively in urban and rural areas. About 47.2% microcephalies were low birth weights. The perinatal mortality was 60.2%.Conclusion:The incidence of microcephaly in China is not different from that in other countries, but it was higher in females. The quality of microcephaly is inferior and the perinatal mortality is high.\;