亚急性甲状腺炎患者血清甲状腺激素及免疫球蛋白测定

Determination of serum thyroid hormone and immunoglobulin in subacute thyroiditis

目的 探讨亚急性甲状腺炎患者血清免疫球蛋白与甲状腺激素关系及临床意义。方法 采用放射免疫分析法 (RIA)和免疫浊度法对亚急性甲状腺炎患者和正常人血清甲状腺激素和免疫球蛋白分别进行测定。结果 亚急性甲状腺炎患者血清中IgG、IgM、IgA、C3 、C4分别为 (2 0 .3± 7.0 )、(1.6 0± 0 .36 )、(2 .10± 0 .5 1)、(1.10± 0 .18)、(0 .5 1± 0 .0 6 ) g/L ,正常对照分别为 (12 .1± 2 .2 )、(1.2 9± 0 .34)、(2 .0 0± 0 .4 2 )、(1.0 8± 0 .13)、(0 .5 0± 0 .0 5 )g/L。亚急性甲状腺炎患者IgG、IgM均显著升高 (P <0 .0 5 )。亚急性甲状腺炎游离三碘甲腺原氨酸 (FT3 )、游离甲状腺素 (FT4)升高者分别为 :2 5 .8%、19.3% ,且FT3 、FT4升高者IgG、IgM分别有 75 .0 %、87.5 %高于其平均值。结论 IgG、IgM升高说明亚急性甲状腺炎患者体液免疫应答增加 ,且与甲状腺激素水平有一定关系 。

Objective To investigate the relationship of serum thyroid hormone and immunoglobuln in subacute thyroiditis and its clinical significance. Methods Thyroid hormone was measured by radioimmunoassay and immunoglobuln was measured by immunoturbidimetric method. Results The concentration of IgG、IgM、IgA、C 3、C 4 of patient group was:(20.3±7.0)、(1.60±0.36)、(2.10±0.51)、(1.10±0.18)、(0.51±0.06) g/L, and control group was: (12.1±2.2)、(1.29±0.34)、(2.00±0.42)、(1.08±0.13)、(0.50±0.05) g/L. The former was higher than the control group( P <0.05). Free triiodothyronine(FT 3) of 25.8 per cent patients and free tetraiodothyronine(FT 4) of 19.3 per cent patients were increased among them 75.0 per cent IgG and 87.5 per cent IgM concentration were higher than its mean. Conclusion Increasing of IgG or IgM correlates with thyroid hormones, it can be used as monitoring and prognostic factor.