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低氧诱导因子-1与恶性肿瘤的研究进展 被引量:9

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摘要 肿瘤发生、发展是一个克隆性选择的结果 ,癌基因的激活突变或抑癌基因的失活突变 ,导致HIF 1α的表达和 /或其活性升高 ,后者介导细胞对低氧的适应性反应 ,包括刺激新生血管形成和促进糖酵解过程 ,最终导致细胞在不断增生的同时获得转移和浸润的能力。
出处 《国外医学(生理病理科学与临床分册)》 2002年第1期17-19,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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