转化生长因子β_1及其受体与大肠癌
摘要
转化生长因子 β1(TGF β1)是人体多种组织细胞的生长调控因子 ,其对大多数正常细胞及上皮性肿瘤细胞具有生长抑制作用。转化生长因子 β1Ⅱ 型受体 (TβRⅡ)的表达减少是机体细胞逃逸TGF β1负调控作用从而发生癌变的一个重要改变。TGF β1及其受体的改变与大肠癌关系密切。
出处
《国外医学（生理病理科学与临床分册）》
2002年第1期19-22,共4页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献16
-
1Markowitz S, Wang J, MyeroffL, etal. Inactivation of the type Ⅱ TGF-βreceptor in colon cancercells with microsatellite instability[J]. Science (Washington DC), 1995,268:1336 - 1338.
-
2Wang J, Han W, Zborowska E, et al. Reduced expression of transforming growth factor βtype Ⅰ receptor contributes to the malignancy of human colon carcinoma cells[J]. J Biol Chem, 1996,271 (29): 17366 - 17371.
-
3MacKay SLD, Yaswen LR, Tarbuzzer RW, et al. Colon cancer cells that are not growth inhibited by TGF-β lack functional type Ⅰ and type Ⅱ TGF-βreceptors[J]. Ann Surg, 1995,221(6):767-777.
-
4Matsushita M, Matsuzaki K, Date M, et al. Down-regulation of TGFbeta receptors in human colorectal cancer: implications for cancer development[J]. Br J Cancer, 1999,80( 1 - 2): 194 - 205.
-
5Visser JA, Tnemmen APN. Downstream factors in transforming growth factor-βfamily signaling[J]. Mol Cell Endocrinol, 1998,146:7 - 17.
-
6Riggins GJ, Kinzler KW, Vogelstein B, et al. Frequency of Smad gene mutations in human cancers [J]. Cancer Res, 1997,57 ( 13 ): 2578 -2580.
-
7Heldin CH, Miyazono K, Dijke PT. TGF-β Signalling from cell membrane to nucleus through SMAD proteins[J]. Nature, 1997,390:465 -471.
-
8Knshiyama Y, Fukuda R, Suetsugu H, et al. Site-dependent production of transforming growth factor beta 1 in colonic mucosa: its possible role in tumorigenesis of the colon[J]. J Lab Clin Med,2000,136(3) :201 -208.
-
9Shim KS, Kim KH, Hah WS, et al. Elevated serum levels of transforming growth factor-beta 1 in patients with colorectal carcinoma: its association with tumor progession and its significant decrease after curative surgical resection[J]. Cancer, 1999,85(3) :554 - 561.
-
10Tsushima H, Kawata S, Tamura S, et al. High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression[J]. Gastroenterology, 1996,110(2) :375 - 382.
-
1漆云翔,叶菲,宋晏琼.TGF-β RII与HER-2阴性乳腺癌患者预后的关系研究[J].中国普通外科杂志,2016,25(5):756-760. 被引量：3
-
2吴江,王中秋,朱虹.胰腺癌淋巴管生成的研究进展[J].医学研究生学报,2009,22(9):976-980. 被引量：2
-
3屈晶晶,李敏,安健,胡成平.上皮-间质转化与肿瘤转移及干细胞的研究进展[J].国际呼吸杂志,2015,35(12):939-942.
-
4邹璎.转化生长因子β_1Ⅱ型受体在结直肠癌及癌前病变中的的表达[J].浙江临床医学,2005,7(2):118-119. 被引量：1
-
5李朝英,李刚.甲胎蛋白的生物学功能[J].世界华人消化杂志,2011,19(14):1436-1440. 被引量：5
-
6蒋立艳,王自能,郭祖文,唐福新,曹水良,赖新强,唐海兰.卵巢浆液性囊腺癌神经内分泌细胞的形态学观察[J].实用医学杂志,2007,23(12):1792-1794.
-
7李晨羲,张宗峰.宫颈癌中EMT相关因素的研究进展[J].现代肿瘤医学,2015,23(21):3204-3207. 被引量：3
-
8梁景文,章翔,王占祥,杨利孙,张永琴.TGFβ_1在脑胶质细胞瘤中的表达和意义[J].第四军医大学学报,2001,22(23):2161-2161.
-
9邹璎.转化生长因子β_1Ⅱ型受体在结直肠癌中的表达[J].中国肿瘤,2004,13(9):593-594.
-
10任周新,沈俊岭,李亚,余海滨.TGF-β诱导肿瘤细胞上皮-间充质转化的调节及信号转导机制研究进展[J].安徽医科大学学报,2015,50(1):124-128. 被引量：5
