针刺对大鼠学习记忆的促进作用与其抗氧化作用的关系

Relationship Between Promoting Effect of Acupuncture on Learning Memory of Rats and Its Anti-oxidation Effect

目的 研究针刺对大鼠学习记忆的影响 ,分析针刺影响大鼠学习记忆与其影响脑内自由基反应的关系。方法 采用水迷宫测试正常大鼠和亚硝酸钠所致痴呆大鼠的学习记忆能力 ,同时测定被试大鼠脑内过氧化脂质含量和超氧化物歧化酶活性。结果 针刺能提高正常大鼠的学习记忆能力 ,并能拮抗亚硝酸钠对大鼠空间识别记忆巩固的破坏。针刺组大鼠大脑皮层的LPO含量低于模型组 ,而SOD活性则高于模型组 ,具有显著性差异 (P <0 .0 5或 <0 .0 1) ,SOD/LPO比值与其记忆成绩呈负相关性。

OBJECTIVE To investigate into the effect of acupuncture on the learning memory of rats and analyze the relationship between the effect of acupuncture on learning memory and its effect on reaction of free radicals. METHOD Water labyrinth was used to test the learning memory of normal rats and dementia rats induced by sodium nitrite. The content of brain peroxidation lipid and the activity of superoxide dismutase of the rats were also determined. RESULT Acupuncture could improve the learning memory of normal rats and antagonize the impairment in the learning memory of rats induced by sodium nitrite. In the acupuncture group, the content of LPO in the brain cortex was lower than that in the model group, but the SOD activity was higher than that in the model group ( P < 0.05 or P <0.01), with negative correlation between SOD/LPO ratio and learning ability. CONCLUSION There is some relationship between the effect of acupuncture in promoting the learning memory of rats and its effect in inhibiting brain free radical reaction.