原发性肝淋巴瘤临床病理特点及治疗(附5例报告)

Clinicopathological features and treatment of primary lymphoma of liver: a report of 5 cases

目的 探讨原发性肝淋巴瘤 (PLL)的临床病理特点及治疗方法。方法 回顾性分析 5例原发性肝淋巴瘤的病因、临床表现、病理特征和治疗结果。结果 5例均有上腹痛及发热 ,3例有淋巴瘤B症状 (发热、盗汗、体重减轻 )。有 3例合并慢性肝炎或肝硬化。组织学检查所有病例均为非霍奇金淋巴瘤。 1例行单纯手术切除 ,3例行手术 +化疗 ,随访生存超过 12个月者 3例。结论 上腹痛、淋巴瘤B症状及血清乳酸脱氢酶增高是PLL的常见表现 ,手术切除和联合化疗是有效的治疗方法。

Objective To investigate clinical and pathological features of primary lymphoma of the liver (PLL)and explore the methods for its treatment. Methods Etiological factors, clinical situation, pathological features and therapeutic results of five cases of PLL were retrospectively analyzed. Results Chronic hepatitis or cirrhosis before onset of hepatic lymphoma was noted in 3 cases. The main clinical manifestations were epigastric pain and fever in 5 and B symptoms of lymphoma (fever, night sweats, weight loss) in the other 3. Histological examination showed that all the cases were non-Hodgkin's lymphoma. Their treatments included resection only in 1 and resection followed by combined chemotherapy in 3. Three patients survived over 12 months after the treatments. Conclusions The common manifestations of PLL are epigastric pain, B symptoms and the elevation of lactate dehydrogenase. Surgical resection and combined chemotherapy may be the most effective approach for treatment of PLL.