声带小结及声带息肉的组织病理学研究

Pathological studies of vocal polyps and vocal nodes

目的 :从组织病理学方面探讨声带小结和声带息肉的异同。方法 :对 14 4例声带小结或声带息肉患者的手术标本进行组织病理学分析。结果 :病程较短者 ,声带小结和声带息肉组织学表现无统计学差异 (P >0 .0 5 ) ;病程较长者 ,声带小结上皮异常角化及基底膜增厚较明显 ,声带息肉基底膜则较薄或仅有轻度增生 ,同时有明显的水肿、血管扩张及血管增生。结论 :声带损伤后病理修复的不同阶段产生了声带小结和声带息肉 。

Objective:In order to investigate the pathological differences and similarities of vocal nodes and vocal polyps.Method:144 samples of vocal nodes and vocal polyps were examined by an experienced pathologist.Result:There were no significant statistical difference in short term vocal nodes and vocal polyps. In long term vocal nodes and vocal polyps, vocal nodes had thickened basal membrane, and abnormal keratinization of epithelium, vocal polyps had thin or discrete thickening of basement membrane, more pronounced edema, dilated vessels or growth of new blood vessels. Conclusion:It proved that vocal nodes and polyps are the result of 'microtraumas ' occurring at various phases of wound repair, thus accounting for the homogeneity and heterogeneity of histological and clinical manifestations.