HPV_(11)对小儿喉乳头状瘤预后的影响

Evaluating the impact of human papilloma virus infection on prognosis of juvenile laryngeal papilloma

目的 :研究人乳头状瘤病毒 (HPV)型别对小儿喉乳头状瘤 (JLP)预后的影响。方法 :应用聚合酶链反应结合斑点杂交技术对 2 5例JLP的石蜡标本进行HPV定型分析 ,并统计HPV11、HPV6 感染组的气管切开率和术后复发率。结果 :HPV总检出率为 96.0 % ,其中HPV11为 5 6.0 % ,HPV6 为 4 0 .0 % ,HPV16、18、33无一例阳性。HPV11感染组的气管切开率为 71.4 % ,术后复发率为 85 .7% ;HPV6 感染组的气管切开率为 3 0 .0 % ,术后复发率为4 0 .0 %。两组分别比较 ,其差异均有显著性意义 (P <0 .0 5 )。结论 :HPV6、11与JLP发生密切相关 ,HPV11感染与JLP的喉梗阻和术后复发率相关 ,HPV11感染可作为JLP预后评判的重要依据。

Objective:To evaluate the relationship between human papilloma virus (HPV) and pathological characteristics of juvenile laryngeal papillomas (JLP).Method: Using polymerase chain reaction protocol,we analyzed paraffin embedded tissue in 25 cases of juvenile laryngeal papilloma and determined the HPV type.Result: A total HPV infection positive rate was 96%, and HPV 11 positive rate was 56%,HPV 6 positive rate was 40%.None of all was positive for HPV 16,18,33 ,71% of patients need tracheotomy in HPV 11 infection group,and 30% of patients need tracheotomy in HPV 6 infecting group.The post operation relapse rate in HPV 11 positive group was 86%,and in HPV 6 positive group was 40%.Conclusion: Juvenile laryngeal papilloma is associated with HPV 11 ,HPV 6 infection and we considered that HPV 11 infection may be the important guideline of the evaluation of disease prognosis.