乙型肝炎病毒感染者前S_1蛋白检测的临床观察研究

Clinical Observation for Patients Infected with Hepatitis B Virus By Testing PreS_1

目的 观察前S1 蛋白在急慢性乙型肝炎及乙肝携带者中的不同变化 ,评估乙肝病人的病情预后。方法 采用前展性队列研究方法 ,选择 84例不同乙肝病毒感染者 ,其中急性乙型肝炎 10例 ,慢性乙型肝炎 44例 ,乙肝病毒携带者 3 0例。按间隔 0、1、3、6月检测随访前S1 蛋白 ,结合肝功能和临床进行观察研究。结果 前S1 蛋白在急慢性肝炎发作期间及恢复期间无统计学差异 ;急性肝炎发作期与恢复期间 ,慢性肝炎发作期与恢复期间 ,急慢性肝炎与乙肝病毒携带者间都有统计学差异。结论 PreS1 与HBV的活动有关 ,与肝炎的病程长短无关 ,PreS1

Objectives:The objective of this study was to eluvatethe the prognosis of the patients infected with hepatitis B by observation the varity of the result of PreS1.The method of this study was the Prospective Cohort Study,Selecteing 84patients infected with hepatitis B Virus.Including 10 patients as Acute Hepati-tis B,44 patients as Chronical Hepatitis B,and 30 patients as Carrying Hepatitical B Virus.Dynamic obser-vation combining clinic the variety of PreS 1 by testing PreS 1 and liver function interval 0,1,3,6 months.Founding that PreS 1 connecting with the activity of HBV,not relation to the period of Hepatitis B;carriers of hepatitical B virus apting to hepatitis B in persisting postive of PreS 1.