慢性精神分裂症住院病人迟发性运动障碍研究

Tardive dyskinesia among in-patients with chronic schizophrenia.

目的 了解慢性精神分裂症住院患者迟发性运动障碍 (TD)的发生率并进行危险因素分析。方法 对4 4 3例慢性住院精神分裂症患者用自制患者情况调查表、阳性和阴性症状量表 (PANSS)、不自主运动量表 (AIMS)进行调查 ,并行二分量Logistic回归分析。结果 住院精神分裂症患者TD发生率为 2 1.7% ,其中男性为 2 0 .3% ,女性为2 7.3%。回归分析显示 ,年龄、性别、PANSS量表总分、目前抗精神病药物日剂量与TD的发生密切相关。结论 慢性精神分裂症住院患者的TD发生率很高 ,老年女性伴严重精神症状、每日药量较低时比男性更易患TD。

Objective To explore the incidence and risk factors of tardive dyskinesia among in patients with schizophrenia.Methods A self designed inventory, Positive and Negative Syndrome Scale (PANSS) and Abnormal Involuntary Movement Scale (AIMS) were employed to measure 433 in patients with schizophrenia. Binary Logistic Regression analysis was carried out.Results The incidence of tardive dyskinesia among in patients with schizophrenia is 21.7% (male 20.3%, female 27.3%). The risk factors of tardive dyskinesia included age, sex, the total scores of PANSS and daily dosage of antipsychotics.Conclusions The incidence of tardive dyskinesia is high. Old women are more at risk of tardive dyskinesia than men, especially those with deficient mental state and lower daily drug dosage.