大骨节病分子机理的流行病学研究

To study the molecular mechanism in etiology of Kashin-Beck Disease with epidemiologic method

目的 用流行病学方法研究大骨节病分子机理,找出重点,确定主攻方向。方法 在流行病学调查分析中使用“分子病理、生物标志”概念,观察大骨节病的发病机理。结果 在论证发病机理的7个环节（易感者、病因、体内检出、分子损伤、亚临床病例、典型病例、病因链阻断）中,仅有体内检出一项尚待补充外,其他都是已经完成或基本完成了的。缺欠在于目前国内外都还没有解决人体内T-2毒素含量的测定问题。结论 中国大骨节病研究首先解决了一级预防的方法问题,赢得了时间,给了若干尚待探讨的基础性工作以充分的活动空间,可以精益求精,有备而发了。

ObjectiveT o study the etiology of Kashin-Beck Disease (KBD) with epidemiologic method, and accordingly to definite the key problems for future studies. Methods In the research we had used methods of molecular pathology and molecular epidemiology to study the mechanism of KBD. Routinely there are 7 courses involved in this process; they are, the susceptible population, the cause of KBD, the causal substance detectable from the body of patients, the observation on the subcHnical cases, the typical cases and how to block the KBD causal chain. Results Of the whole 7 courses mentioned above all but one had not been resolved yet, it is how to find and detect the T-2 toxin or its products of metabolism from human body. Conclusions In our country, the studies for KBD had achieved formerly the success in establishment of the primary strategy of KBD prevention before 1995. So that we gained sufficient time and spaces to study several fields in basic medicine for example to identify the T-2 toxin and its products of metabolism from patients body.