扶正平喘中药对哮喘豚鼠模型气道嗜酸细胞浸润的影响

THE EFFECT OF TRADITIONAL CHINESE MEDICINE OF RIGHT UP-BRINGINGAND ASTHMA RELIEVING ON EOSINOPHIL INFILTRATIONIN AIRWAYS OF ASTHMATIC GUINEA PIGS

目的 :观察扶正平喘中药对豚鼠哮喘发作的预防和治疗作用并探讨其作用机理。方法 :4 8只豚鼠随机分成 4组 :正常对照组、哮喘模型组、地塞米松组、扶正平喘中药组。用鸡卵清蛋白 (OVA)制成哮喘模型。地塞米松组和扶正平喘中药组分别于激发前 3d灌药至激发后 3d停药。计数外周血嗜酸细胞 (EOS) ,观察肺切片中EOS的浸润情况。结果 :哮喘组豚鼠外周血EOS明显增多 ,肺内支气管有大量的EOS浸润 ;地塞米松组、扶正平喘中药组豚鼠外周血EOS有不同程度增多 ,肺内支气管有不同量的EOS浸润 ,均少于哮喘组。结论 ;扶正平喘汤可降低外周血EOS ,抑制肺内ESO浸润。

Objective: To observe the preventing and treating effect of traditional chinese medicine of right upbringing and asthma relieving on asthmatic guinea pigs and explore its action mechanism. Method:48 guinea pigs were divided into four groups randomly:the groups of normal control.asthma,dexamethasone and traditional chinese medicing(TCM),The models of guinea pigs sensitised by OVA were made.The difference of peripheral blood eosinophil count (PBEC)and eosinophil infiltration in slices of lung were compared among four groups.Results:The PBEC in groups dexamethasone and TCM was lower than that in group asthma The eosinphil infiltration in bronchi of lung of groups dexamethasone and TCM was less than that of group asthma.Conclusion:TCM of right upbringing and asthma relieving can reduce the PBEC and restrain the eosinophil infiltration in lung,and the action effect was similar to the anti-inflammatory effect of glucocorticoid.