吸烟对男性精液质量的影响及相关性研究

Study of Correlation and Effect of Smoking on Semen Quality of Men

目的 :探讨吸烟对男性精液质量的影响及相关性。 方法 :30 1例不育男性 (110例非吸烟者和 191例吸烟者 ) ,对照组为 6 1例已生育 1个或 1个以上子女的健康男性 (无吸烟史 )。根据吸烟量和烟龄分为不同吸烟量组和不同烟龄组。检测了精液各参数 (精液量、精液pH、精子计数、精子存活率及前向运动级别等 )和精浆Zn、Cu、超氧化物歧化酶 (SOD)含量。 结果 :中、大量或长时间吸烟组精液量 ,精子计数 ,精子存活率及前向运动级别 ,精浆Zn、Cu和SOD含量较非吸烟组显著降低 ,精液pH显著升高 (P均 <0 .0 1)。精子计数 ,精子存活率及前向运动级别 ,精浆Zn、Cu、SOD含量与吸烟量和烟龄之间呈高度负相关 (P <0 .0 1)。 结论 :吸烟对精液各参数的影响存在着量 效和时 效关系 ,中。

Objectives: To study the correlation and effect of smoking on the semen quality of men . Methods: 61 men, non smoker, who had one or more children as normal fertility control group and adult males attending the infertility clinic, including 110 non smokers and 191 smokers, were recruited for the study. The smokers were divided into subgroups according to the amount and duration of smoking. Semen parameters(volume,sperm density, viability, motility and morphology)were examined and seminal plasma contents of Zn ,Cu and superoxide dismutase (SOD) were determined. Results: The semen volume,pH,sperm density, viability and forward progression, as well as the seminal plasma contents of Zn, Cu and SOD were much lower in the medium, heavy and long term smokers than in the non smokers( P <0.01). The sperm density, viability and forward progression, and the seminal plasma Zn, Cu and SOD levels were negatively correlation with the amount and duration of cigarette smoking( P <0.001). Conclusions: The effect of smoking on semen parameters of infertile men were dose effect and time effect relationship. Medium, heavy and long term smoking adversely affected the semen quality in a population of men visiting the infertility clinic.