体外射频联合α_1-肾上腺素能受体阻滞剂治疗非细菌性前列腺炎和前列腺痛疗效观察

Treatment of External RF Hyperthermia Combining with α_1 -Adrenergic Receptor Blocker for Patients with Prostatodynia and Chronic Non bacterial Prostatitis

目的 :探讨慢性非细菌性前列腺炎 (CNP)和前列腺痛 (PD)的治疗方法。 方法 :136例CNP和PD病人随机分为两组 ,实验组体外射频 (ERFH)联合α1 肾上腺素能受体阻滞剂Terazosin口服 ,对照组仅行ERFH ,治疗 12周后随访 ,观察治疗前后尿流动力学指标、前列腺液常规及前列腺炎症状评分的变化。 结果 :治疗后前列腺炎症状评分、最大尿流率 (MFR)、平均尿流率 (AFR)两组均有明显改善 ,实验组改善及提高程度较对照组更为显著(P <0 .0 5 )。最大尿道压 (MUP)及最大尿道闭合压 (MUCP)实验组较治疗前明显降低 (P <0 .0 5 ) ,前列腺液常规中白细胞数实验组较治疗前降低明显 (P <0 .0 5 ) ,MUP、MUCP在对照组治疗前后变化不明显 (P >0 .0 5 )。 结论 :ERFH联合Terazosin治疗CNP和PD安全有效 ,药物副作用小 。

Objectives: To evaluate a new effective treatment for prostatodynia(PD) and chronic non bacterial prostatitis(CNP). Methods: One hundred and thirty six patients suffered from PD or CNP were divided randomly into experiment group( n =76) ,which were treated with external RF hyperthermia(ERFH) combining with α 1 adrenergic receptor blocker Terazosin for 12 weeks ,and control group( n =60), which were only treated with ERFH. Symptoms scores, urodynamic indexes and expressed prostate secretion were recorded pre and post treatments. Results: MFR and AFR were significantly improved and symptoms scores significantly decreased in both groups( P <0.05). The efficacy was better in experiment group than that in control group. The combination treatment also led to a significantly decrease in MUP and MUCP( P <0.05). Additionally, the leucocytes in expressed prostate secretion were also reduced in experiment group( P <0.05). Conclusions: Treatment of ERFH combining with α 1 adrenergic receptor blocker for patients with PD or CNP was effective and had little side effect,while the future curative effect should be observed furtherly.