2Rosenberg L.Pancreatic cancer.A review of emerging therapies.Drugs,2000;59:1071
3Weidner N,Semple JP,Welch WR,et al.Tumor angiogenesis and metastasis_correlation in invasive breast carcinoma.N Engl J Med,1991;324(1):1~8
4Folkman J.Anti_angiogenesis:new concept for therapy of solid tumors.Inn Surg,1972;175:409~416
5Shing Y,Folkman J,Sullivan R,et al.Heparin affinity:purification of a tumor_derived capillary endothelial cell growth factor.Science,1984;223:1296~1299
6Folkman J.Angiogenesis in cancer,vascular,rheumatoid and other disease.Nature Med,1995;1(1):27~31
7Folkman J.Clinical complications of research on angiogenesis.N Engl J Med,1995;333(26):1757~1763
8Carron CP,Meyer DM,Pegg JA,et al.A peptidomimetic antagonist of the integrin alpha(v) beta 3 inhibits leydig cell tumor growth and development of hypercalcemia of malignancy.Cancer Res,1988;58(9):1930~1935
9Freeman MR,Schneck FX,Gagnon ML,et al.Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor:a potential role for T cells in angiogenesis.Cancer Res,1995;55:4140~4145
1Diehol SJ,Lehmann KJ,Sadifck M,et al.Pancreatic cancer:value of dualphase helical CT in assessing resictability.Radiology,1998;206(2):373~378
2Freeny PC,Marks WM,Ryan JA,et al.Pancreatic ductal adenocarcinoma:diagnosis and staging with dynamic CT.Radiology,1988;166(1):125~133
3Zeman RK,Cooper C,Zeiberg AS,et al.TNM staging of pancriatic carcinoma using helical CT.AJR,1997;169(2):459~465
4Hollett MD,Jorgensen MJ,Jeffery RB Jr.Quantitative evaluation of pancreatic ehnancement during dual-phase helical CT.Radiology,1995;195:359
5Zeman RK,Silveman PM,Ascher SM,st al.Helical(spiral)CT of the pancrease and biliary tract.Radiol Clin North Am,1995;33(5):887~902
6Inokuma T,Tamaki N,Torizuka T,et al.Evaluation of pancreatic tumors with positron emission tomography and F-18 fluorodeoxyglucose:Comparison with CT and US.Radiology,1995;195:345~352
7Kalender WA,Polacin A,Sus C.A comparison of conventional and spiral CT with regard to contrast and spatial resolution:an experimental study on the detection of spherical lensions.J Comput Assist Tomogr,1994;18:167~176
8Kobayashi G,Fujita N,Noda Y,et al.Evaluation of helical scanning in the diagnosis of pancreatic diseases.Nippon Shokakibyo Gakkai zasshi,1994;91:2083~2093
9Lentschig MG,Reimer P,Rummeny E,et al.The role of spiral CT and MRI in the preoperative diagnostic of pancreatic carcinoma.Radiology,1996;406~412
10Hommeyer S,Freenny PC,Crabo LG.Carcinoma of the head of the pancreas:evaluation of the pancreaticoduodenal veinswith dynamic CT-potential for improved accuracy in staging.Radiology,1995;196:233~238
2[1]Vlodavsky I,Friedmann Y.Mammalian heparanase gene cloning ,expression and function in tumor progression and metastasis.Nat Med,1999;5(7):793~802
3[2]Hulett MD,Freeman C.Cloning of mammalian heparanase,an important enzyme in tumor invasion and metastasis.Nat Med,1999;5(7):803~809
4[5]Miao HQ.Elkin M.Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides .Int J Cancer,1999;83(3):424~431
5[6]Parish CR,Freeman C.Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel vitro assays for angiogenesis and heparanase activity.Cancer Res,1999;59(14):3433~3441
6[7]Koliopanos A,Friess H.Heparanase expression in primary and metastatic pancreatic cancer.Cancer Res,2001;61(12):4655~4659
7[8]Ginath S,Menczer J.Expression of heparanase ,Mdm2,and erbB2 in ovarian cancer.Int J Oncol,2001;18(6):1133~1144
8[9]Mikami S,Ohashi K,et al.Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas.Jpn J Cancer Res,2001;92(10):1062~1073
9[10]Vlodavsky I,Friedmann Y.Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis .J Clin Invest,2001;108(3):341~347
10[11]Elkin M,Ilan N.Heparanase as mediator of angiogenesis mode of action.FASEB J,2001;15(9):1661~1663