中西医结合治疗增生型狼疮肾炎38例临床观察

Clinical Observations of Integrated Treatment of 38 Proliferative Lupus Nephritis Cases

目的 :观察中西医结合治疗增生型狼疮肾炎 (PLN)的效果。方法 :将 76例 PLN患者随机分为西医组和中西组。西医组予强的松和环磷酰胺治疗 ;中西医组在西医组治疗的基础上加狼疮方。 1 2个月后观察两组的治疗效果、复发率、副作用和生活质量。结果 :中西医组疗效优于西医组(P<0 .0 5 )。中西医组完全缓解 2 6 .3 % ,显著缓解 5 2 .6 % ,部分缓解 1 3 .2 % ,无效 7.9% ,西医组完全缓解 1 0 .5 % ,显著缓解 3 9.5 % ,部分缓解 3 .42 % ,无效 1 5 .8%。中西医组复发率低于西医组 ,分别为 1 0 .5 %和 3 4 .2 % ,P<0 .0 5 ,中西医组副作用少 ,生活质量改善优于西医组 (P<0 .0 5 )。结论

Objective: To observe the therapeutic efficacy of integrating treatment of proliferative lupus nephritis (PLN). Methods:76 PLN cases were divided at random into 2 groups: Western medicine group ( treated with deltasone and cytoxan) and TCM group (treated with deltasone and cytoxan as well as TCM remedy and Lang-Chuang-Fang). Evaluations were carried out 12 months later on the therapeutic efficacy, recurrence rate, side effects and life quality.Results: The therapeutic effectiveness in the integrated group was better than in the western medicine group(P<0.05).Complete remission rate was 26.3% vs 10.5%. Significant remission rate was 52.6% vs 39.5%. Partial remission rate was 13.2% vs 34.2%. Ineffective rate was 7.9% vs 15.8% (Integrated group vs western medicine group).Fewer side effects were observed with better life quality (P<0.05). Conclusion:Integrated treatment of PLN cases was better than that with unique Western medicine.