摘要
目的 探讨晚期血吸虫病 (晚血 )发生的危险因素。 方法 1∶ 1、1∶ 2配对病例 -对照研究。对照组为健康人 ,慢性血吸虫病 (慢血 )患者 ,每组调查 2 13例。调查内容包括 :血吸虫病患病史、治疗史、疫水接触史、社会经济状况及营养状况等。检测细胞、体液免疫水平、 5项乙肝血清标志物 (HBVMs)和 ABO血型及 B超等。用 SAS软件 ,以 1∶ 1、1∶ 2配对单因素和逐步条件 logistic回归分析。 结果 血吸虫病检查次数 (OR=1.16 8~ 1.311)、首次患血吸虫病距末次治疗间期 (OR=1.14 2 )和距本次调查间期 (OR =1.0 89)、HBs Ag+ (OR=4 .6 83~ 10 .75 9)、HBc Ab+ (OR=2 .873)、HBs Ag+ +HBe Ab+ +HBc Ab+ (OR=7.6 0 4 )为晚血发病危险因素 ;晚血患者人均住房面积较小、年均收入较低 ;未发现晚血与 ABO血型的关联性。 结论 晚血的发生与血吸虫的反复感染、血吸虫病治疗不及时、不彻底及感染间期长有关 ,合并乙肝感染。
Objective To investigate risk factors for the development of advanced schistosomiasis. Methods The case\|control study was designed with a match of 1∶1 and 1∶2. Healthy persons and chronic schistosomiasis patients were used as control. Each group was composed of 213 cases. Items investigated included: history of schistosomiasis and treatment, exposure to the contaminated water, social\|economical condition and nutritional status, other concomitant diseases. Cellular and humoral immunity, HBVMs and ABO blood groups were also detected. Statistical analysis was performed by 1∶1 and 1∶2 matched single and stepwise conditional logistic regression analysis with SAS software. Results By stepwise conditional logistic regression analysis, it was revealed that number of schistosomiasis examination(OR=1\^168-1\^311), interval from first infection to last treatment(OR=1\^142), interval from first infection to this investigation (OR=1\^089), \{HBsAg\++\}(OR=4\^683-10\^759), \{HBcAb\++\} (OR=2\^873), \{HBsAg\++\}+\{HBeAb\++\}+\{HBcAb\++\}(OR=7\^64) were risk factors of developing advanced schistosomiasis. The average living space and cellular immunity were lower in advanced schistosomiasis patients than others. No association was found between advanced schistosomiasis and ABO blood groups. Conclusion The development of advanced schistosomiasis is associated with repeated infections, and delayed or incomplete treatment. Combined infection with hepatitis B, poor socio\|economic conditions and impaired cellular immunity may increase the pathogenetic risk of schistosomiasis.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2002年第1期21-24,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
世界银行贷款资助项目 (JRMC 5- 1 4 )~~