摘要
目的 由于对HBV感染的认识正在不断深入,抗病毒治疗急待寻找判定效果的可靠方法,HBV DNA检测,特别是血液和肝组织定量检测显得极为重要。方法 在HBV感染者作肝活检时随机留取小粒肝组织,同时采血作HBV DNA定量检查。结果 急慢性HBV感染病例均示肝组织内HBV DNA检查明显高于血内检出率,同时肝组织HBV含量明显高于血液内含量。结论 肝组织检测HBV DNA可以明显提高HBV感染诊断率,血内HBV DNA阴转时不能说明肝组织内亦已阴转,血内HBV DNA阴转不宜随即停止治疗。
Objective Because of further study of HBV infection and evaluating the effects of antivirus treatment, HBV DNA assay, especially quantification test of HBV DNA in blood and liver tissue has important significance. Methods A small piece of liver tissue from liver biopsy and 2ml of blood were collected at random from HBV infectcd patients for HBV DNA quantification test. Results All the HBV DNA positivc rate of liver tissue from both acute and chronic HBV infected patients was higher than that of blood and the quantity of HBV DNA from liver tissue obviously higher than that of blood ,too. Conclusion The assay of liver tissue HBV DNA could raise the possibility of HBV infection diagnosis, seroconversion does not mean no HBV DNA in hepatocytes and treatment should not be stoped at once while seroconversion of HBV DNA.
出处
《实用医药杂志》
2002年第2期81-83,共3页
Practical Journal of Medicine & Pharmacy