老年人大肠癌中PCNA和P^(53)、Pgp表达及意义

Expression and Significance of PCNA, P^(53) and Pgp in Colorectal Carcinoma

目的 研究大肠癌中PCNA、P53、Pgp的表达及与临床病理特征间的关系。方法 采用S -P免疫组化方法检测 2 35例老年人大肠癌中PCNA、P53和Pgp的表达。结果 大肠癌中PCNA、P53、Pgp的阳性表达率分别为 87 2 %、74 9%及 4 5 9%。癌组织PCNA与P53同时阳性表达者占 5 7 7% (135 / 2 35 )。PCNA与P53的阳性表达与分化程度、浸润深度、淋巴结转移密切相关 ;Pgp表达与临床病理指标无相关性。结论 PCNA和P53可能与大肠癌的发生有关 ,在大肠癌的发生中可能起协调作用。

Objective To study the relation between the expression of PCNA, P 53 , Pgp and clinical pathological parameters in colorectal carcinoma. Methods The expression of PCNA, P 53 and Pgp were detected with immunohistochemical technique (S-P) in 235 cases of carcinoma in large intestine. Results The positive rates of PCNA, P 53 and Pgp expression were 87.2%, 74.9% and 45.9% respectively. The positive expression of PCNA and P 53 were occurred in 57.7% of the 235 cases. The positive expression of PCNA and P 53 in the tumor was correlated with clinical pathological parameters. Conclusion PCNA and P 53 might play a combined role in colorectal carcinoma occurring. Pgp had popular significance in the choice of chemotherapy for colorectal carcinoma.