转化生长因子-α在人胰腺癌表达的免疫组化研究

Immunochemical Study of expression of TGF-α in occurrence of pancreatic carcinoma

应用免疫组化 ABC法对 30例胰腺癌组织转化生长因子 - α(TGF- α)的表达进行研究 ,以探讨 TGF- α的异常表达与胰腺癌发生的关系。结果表明 TGF- α在胰腺癌组织和正常胰腺组织的阳性表达率有显著差异 (P<0 .0 5 ) ;TGF- α的表达与胰腺肿瘤的大小和转移行为无关 ,而在 期和 期胰腺癌中的阳性表达率显著高于 期和 期胰腺癌 (P<0 .0 5 ) ,TGF- α可能在胰腺癌发生中起着重要作用。

To investigate the relationship between the expression of transforming growth factor alpha(TGF α)with the occurrence of pancreatic carcinoma(PCA),the expression of TGF α in 30 of PCA tissue and in 20 of normal pancreatic tissue were examined by immunochemical stain.The Results Showed that the positive rate of TGF α in PCA tissue were 53.3% and 13.3% in normal pancreatic tissue.The positive rates of TGF α in PCA were significantly higher than that in normal pancreatic tissue.The expression of TGF α in PCA related to the clinical stage of tumours.TGF α plays important role in occurrence of PCA.