3种预防顺铂所致呕吐方案的成本-效果分析

Cost-effectiveness Analysis of Three Preventing Schemes for Cisplatin-induced Vomiting

目的 :探讨不同药物治疗方案对同一疾病所产生的经济效果。方法 :202例顺铂化疗患者 ,随机分为3组 ,分别给予舒必利、恩丹西酮和甲氧氯普胺进行预防呕吐治疗 ,运用药物经济学的成本 -效果分析方法进行评价。结果 :3种治疗方案中 ,舒必利方案有效率为87 1 % ,1个疗程费用为93 30元 ,有效率每增加1个百分点 ,成本为1 07元 ;恩丹西酮方案有效率为93 5 % ,1个疗程费用为448 26元 ,有效率每增加1个百分点 ,成本为4 79元 ;甲氧氯普胺方案有效率为57 5 % ,1个疗程费用为54 33元 ,有效率每增加1个百分点 ,成本为0 94元。结论

OBJECTIVE:To discuss the economic effects of different therapeutic schemes in the treatment of the same illness.METHODS:202 cases receiving cisplatin chemotherapy were randomly divided into three groups according to the preventing schemes received:group Ⅰ,sulpiride;groupⅡ,ondansetron;groupⅢ,metoclopramide.Data was evaluated using pharmacoeconomic cost-effectiveness analysis.RESULTS:The effective rate of sulpiride was 87.1%,expense of one therapeutic course being 93.30 yuans and increase of 1% effective rate costed 1.07 yuans.The effective rate of ondansetron was 93.5%,expense of one therapeutic course being 448.26 yuans and increase of 1% effective rate costed 4.79 yuans.The effective rate of metoclopramide was 57.5%,expense of one therapeutic course being 54.33 yuans and increase of 1% effective rate costed 0.94 yuans.CONCLUSION:The sulpiride scheme is the most rational one.