兔胸腹部爆炸伤后不同器官微血管通透性的变化

The Changes of Microvessel Permeability in Different Organ Explosive Injury on the Chest-abdomen of Rabbits

目的探讨爆炸性冲击伤后不同组织器官微血管通透性变化的特点及其可能的机理。方法采用雷管对兔的爆炸性冲击损伤模型 ,以及 125I-白蛋白标记的方法 ,观察爆炸性冲击波对兔心、脑、肺、肾、肝组织中的微血管通透性的影响。结果距爆源20cm处的爆炸冲击波平均压力峰值为174 .4kPa,可引起红细胞压积增加为14.9 % (与对照组相比 ) ,血浆丢失为对照的5.12倍 ;距爆源10cm时 ,爆炸冲击波的压力峰值可陡增至1000kPa以上 ,所致白蛋白漏出率为伤前的1.5倍 ,心、脑、肺、肾组织中的残留放射性较对照组增加约1 .6～1.9倍。结论爆炸冲击波能引起红细胞压积明显增加 ,血浆丢失 ,以及心、脑、肺、肾组织中微血管通透性的增加。

Objective To explore the characteristics of microvessel permeability changes after explosive blast injury and its possible mechanism.Methods The model of explosive blast wound on rabbits and the method of 125I_albumin dilution have been used for investigating microvessel permeability changes of heart, lung, kidney, liver and brain in rabbits.Results The average peak pressure in site of 20cm far from explosive center is about 174.4kPa, which can increase the hematocrit by 14.9% than control, and can cause the loss of plasma by 5.12 folds than control group. In the site of 10cm far from explosive center, the pressure of explosive blast can abruptly reach over 10000kPa, which can increase the rate of 125I_albumin escape 1.5 folds than control, and increase the remaining radiation in heart, lung, kidney, liver and brain tissue approximately1.6～1.9 folds than control. Conclusions The explosive blast can cause hematocrit increase,plasma loss, and can increase the microvessel permeability of heart, lung, kidnry,liver and brain in rabbits.